Zwickau is the fourth-largest city of Saxony, Germany, after Leipzig, Dresden and Chemnitz, with around 88,000 inhabitants,. The West S…Zwickau is the fourth-largest city of Saxony, Germany, after Leipzig, Dresden and Chemnitz, with around 88,000 inhabitants,. The West Saxon city is situated in the valley of the Zwickau Mulde, and lies in a string of cities sitting in the densely populated foreland of the Elster and Ore Mountains stretching from Plauen in the southwest via Zwickau, Chemnitz and Freiberg to Dresden in the northeast. Zwickau is the seat of the Zwickau District, the most densely populated district in the new states of Germany.