The NTSB confirmed a UPS cargo plane's left engine separated during takeoff before a fatal Louisville airport crash that killed 12 people and injured 11 others Tuesday.

As the sun set and businesses started to close in Louisville, Kentucky, on Tuesday, the evening calm was suddenly shattered by a giant explosion near the city’s airport.

A UPS cargo plane's left wing caught fire and an engine fell off just before it crashed and exploded after takeoff in Kentucky, a federal official said Wednesday, offering the first investigative details about a disaster that killed at least 12 people,

At least 12 people were killed and several others injured after a UPS plane crashed shortly after taking off from the Louisville International Airport on Tuesday.

The crash of a UPS plane in Louisville, Ky., has disrupted the shipper's air cargo headquarters, delaying some deliveries.

The Federal Aviation Administration (FAA) and the National Transportation Safety Board (NTSB) will lead the investigation into the incident.

Debbie Self, the owner of Stooges Bar in Louisville, said she can't believe "it’s still there" after a UPS plane crashed Nov. 4.