TMZ caught up with the "Yellowstone" actor and his wife of more than 2 decades, Ruvé, after he claimed on Wednesday's "Nothing Left Unsaid" podcast he "lost everything" as a result of being let go from production for ABC's "Scoundrels" ... and then being blacklisted from Hollywood -- all for refusing to get intimate with another woman on screen.

Neal McDonough, who has a strict rule about kissing his onscreen costars, claims Hollywood "turned" on him for the conservative stance.

The actor revealed how his principled stance against on-screen intimacy nearly destroyed his career and identity.