High point totals mean opportunity, and several key matchups stand out as potential fantasy goldmines in Week 10. Week 10 of the NFL season is already upon us, and the challenge of setting lineups and finding an edge in fantasy football only becomes greater than the week before.

The 49ers have suffered several injuries, yet they are still finding convincing ways to win, and they always play Sean McVay and his Rams tough. Keep an eye out for the line to move as the 49ers may get healthier by Sunday, they may even get back starting quarterback Brock Purdy.

After one week back at home in Los Angeles, the Rams will be on the road again in Week 10 for a pivotal matchup with the San Francisco 49ers. It’s a rematch of their Week 5 game that went into overtime,

In Sporting News' Week 10 picks against the spread, Philadelphia and San Francisco getting massive wins for their NFC playoff hopes while the Steelers keep up with the Ravens in the AFC North.

Sean McVay shared another update on Puka Nacua Monday, saying he's "optimistic" about the Rams WR heading into Week 10.

These coaches are friends who joined the division at the same time, are considered offensive geniuses and have had successful tenures as coaches of their respective teams. When they meet on NFL Thursday Night Football, McVay’s Rams are in much better shape when it comes to team health and availability.

The 49ers improved to 6-3 with a Week 9 win over the Giants. See how San Francisco's NFC playoff picture and seeding shape up heading into Week 10.

Rams HC Sean McVay has an update on star WR Puka Nacua, who exited Sunday's blowout win vs. Saints with a chest/ribs injury

Matthew Stafford thrived once again for the Rams while the 49ers were ruthlessly efficient in Week 9 wins.

Matthew Stafford spoke candidly after drawing telling remarks from one of his Los Angeles Rams and defeating the New Orleans Saints.