This mutation is an in-frame deletion resulting in loss of a leucine codon within ApoE’s receptor binding region. Most carriers develop a condition indistinguishable from hyperlipoproteinemia type IIa ...
When acute anemia occurs, very low-density lipoproteins (VLDL), which are involved in lipid transport, are broken down, releasing apolipoprotein E (ApoE). ApoE binds to its receptor (VLDLR) present on ...
Scientists have shown that treating mice with an antibody that blocks the interaction between APOE proteins (white) sprinkled within Alzheimer's disease plaques and the LILRB4 receptor on microglia ...
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