Scientists have discovered that cadherin clusters, which are well known for forming junctions between cells, also play a role in stabilizing the cell cortex. Scientists from the Mechanobiology ...

The thymidine kinase/ganciclovir (TK/GCV) cancer gene therapy approach is based on inducing GCV metabolite cytotoxicity in tumor cells expressing the herpes simplex virus TK gene and exposed to GCV. A ...

Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization ...

Within the junctions, cadherin molecules on the cell surfaces hook onto each other, like a tiny piece of velcro. Cell-to-cell adhesion mediated by cadherins plays an important role in tissue ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 6 (Feb. 7, 2006), pp. 1774-1779 (6 pages) Adhesions of cells to extracellular matrix and adjacent cells ...

Connexin 43 (C×43α1) gap junction has been shown to have an essential role in mediating functional coupling of neural crest cells and in modulating neural crest cell migration. Here, we showed that ...

Scientists from the Mechanobiology Institute, Singapore (MBI) at the National University of Singapore (NUS) have discovered that cadherin clusters, which are well known for forming junctions between ...

Scientists at the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have discovered the molecular mechanisms responsible for the formation of the adherens junction at the ...

Using super-resolution microscopy, an international research team has revealed, for the first time, how cadherin-based cell-cell contacts are organized. The development of super resolution microscopy ...

Microscale 3D printed arches guide cells to form natural self-bonds, improving how soft tissue attaches to medical implants without added proteins. (Nanowerk Spotlight) Efforts to engineer reliable ...