Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

Confinement of enzymes in protein nanocompartments represents a potentially powerful strategy for controlling catalytic activity in cells. By using a simple electrostatically based tagging system for ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

In nature, evolution takes years to sculpt new traits. In the lab, scientists hope to achieve this feat much faster: Being able to evolve proteins with enhanced or novel functions has important ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

A new platform enables fast, scalable protein evolution - opening the door to new therapies and diagnostics, and to predicting resistance mutations across many disease areas. (Nanowerk News) In ...

Scientists have developed a novel approach to modifying enzymes to improve functionality. They designed a new algorithm to make multiple changes to an enzyme sequence at once as compared to the ...