How proteins evolved the ability to form complexes made up of multiple subunits—and what functions this new structure enabled in early multimeric proteins—isn’t well understood. To better understand ...

Previous studies of the interactions of NO with human hemoglobin have implied the predominance of reaction channels that alternatively eliminate NO by converting it to nitrate, or tightly complex it ...

An international team of scientists has found a way to use CRISPR gene editing to help fix sickle cell disease and beta-thalassemia in blood cells isolated from patients. An international team of ...

An important feature of Perutz's trigger mechanism for cooperativity in the reversible oxygenation of hemoglobin (Hb) is the tension along the histidine-metal linkage in deoxyHb and ...

Hemoglobin-based blood substitutes are being developed as oxygen-carrying agents for the prevention of ischemic tissue damage and hypovolemic (low blood volume) shock. The ability of cell-free ...

Knocking out BCL11A switches cellular production of hemoglobin from mutated adult form to normal fetal form. Scientists have managed to correct sickle cell disease (SCD) in adult mice by knocking out ...

Coral reef fish larvae undergo major physiological changes during their short development as they transition from long-distance dispersal in the open ocean to settling on a reef, according to a study ...

(MEMPHIS, Tenn. - August 15, 2016) An international team of scientists led by researchers at St. Jude Children's Research Hospital has found a way to use CRISPR gene editing to help fix sickle cell ...