Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Nucleic acid synthesis underpins life’s vital processes, from replication and transcription to the regulation of gene expression, while polymerase enzymology explores the molecular mechanisms by which ...

Metal-mediated base pairing in nucleic acids represents a transformative approach wherein traditional Watson–Crick hydrogen bonds are replaced or supplemented by coordinate bonds with metal ions. This ...

Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world ...

The chemical origin of life on Earth is a puzzle that scientists have been trying to piece together for decades. Many hypotheses have been proposed to explain how life came to be and what chemical and ...

A few years back, the 50th anniversary of the discovery of the structure of the DNA double helix by biologists James D. Watson and Francis H. C. Crick was grandly celebrated. In fact, it's a double ...

DNA has often overshadowed its single-stranded brethren in many aspects of molecular biology, but as technology continually improves, allowing researchers to manipulate this complex molecule, we are ...

Designing plastics that can be broken down easily after their use phase have often required a trade-off between stability and ...

If you’ve ever learned a language, says Jen Heemstra of Emory University, there are two levels of understanding. First you learn to read text and comprehend it. Then you begin speaking the language ...

A research team led by professor Olivia Merkel, Chair of Drug Delivery at LMU and co-spokesperson of the Cluster for Nucleic Acid Therapeutics Munich (CNATM) has developed the first integrated ...