To record ion channel activity across cell membranes the conventional patch clamp remains the gold standard and is widely used in drug discovery research. However, this traditional method requires ...

Ion channels represent an important class of druggable targets; however, it is generally appreciated in the field that ion-channel targeted drug discovery has been hampered by the unavailability of ...

High-throughput screening (HTS) is a drug discovery strategy used extensively during early-stage pharmaceutical development. The patch-clamp technique remains the gold standard for testing the ...

Flip-the-Tip Technology Uses Standard Glass Pipettes to Achieve Higher Throughput in Ion Channel Screening The pharmaceutical industry has widely recognized patch clamping as the “gold standard” to ...