A real-world study of the association between nivolumab exposure and efficacy in patients with metastatic melanoma. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract ...

Summarized are OATP1B1 drug substrates showing an increase in maximal plasma concentration (C max) and AUC due to interaction with the respective inhibitor (gemfibrozil, ciclosporin or rifampin).

In this project, we optimized a high-throughput fluorescent-based assay to assess transporter activity by measuring uptake of the substrate, ASP+ 4-(4-(dimethylamino)styryl)-N-methylpyridinium. ASP+ ...

Kong’s Pharmaceutical Co. has divulged Ras-related C3 botulinum toxin substrate 1 (RAC1; TC25) inhibitors reported to be useful for the treatment of cancer and neurologic disorders.

Biomimetic Oxidation Can Facilitate the Generation of Metabolites for Testing Purposes For at least a dozen years since the publication of a 1997 FDA guidance on in vitro metabolism studies, drug ...

Scientists once hoped that blocking β-secretase would slow or prevent Alzheimer’s disease. Then came the rude awakening. The inhibitors caused the very thing they were supposed to prevent—cognitive ...