Watch the best plays from San Francisco 49ers quarterback Mac Jones' 319-yard, three-touchdown game against the Los Angeles ...

San Francisco 49ers quarterback Mac Jones throws a 9-yard touchdown pass to tight end Luke Farrell. Detroit Lions quarterback ...

While quarterback Brock Purdy slowly works his way back from injury, the 49ers will once again turn to Mac Jones as the ...

Bryce Huff is off the injury report. Shanahan called him a “huge need,” and the game against the Falcons was Huff’s best of ...

Injuries are a significant factor in the results of NFL action every week, and that certainly will be the case in Week 10 as ...

He’s been as relentlessly positive as ever, cracking up teammates while at the same time inspiring them to do greater things.

Mac Jones has stepped up for the 49ers this season, and his teammates have admired his ability to show toughness while ...

All the energy in the world couldn’t overcome the 49ers losing two turnovers on a fumble by Jauan Jennings and an ...

NFL scores and reports from week 10 of the NFL as the Buffalo Bills are upset by the Miami Dolphins, while the Detroit Lions, ...

SANTA CLARA, Calif. — Quarterback Brock Purdy will miss his sixth straight start for the San Francisco 49ers with a toe ...

WOODLAND HILLS, Ca. The Los Angeles Rams now officially know which quarterback they'll face when they play the San Francisco 49ers on Sunday in Santa Clara. Bo ...

Injuries sideline stars, but new 49ers and Rams defensive talents will battle for NFC West supremacy in this Week 10 rematch.