Anti-PCSK9 antibodies are the jewel in the crown of modern genomic medicine, illustrating what many hope will be a paradigm for future drug discovery.

The promise of a new era of cholesterol management, heralded by the launch of highly effective PCSK9 inhibitors, has been complicated by significant barriers to uptake of the next-generation products ...

For whichever PCSK9 we choose, we get an additional 50% to 60% LDL reduction by using these therapies. So, they work. They lower events. Both trials with PCSK9 inhibitors lowered events by about 15%.

The PCSK9 inhibitors pose a similar, but in many ways more compelling and complex, set of problems. Their target, hyperlipidemia, is one of the most prevalent conditions in the developed world.

MedCo. is a one-drug company whose lead asset, inclisiran, is one of several injectable, cholesterol-lowering meds known as PCSK9 inhibitors. And that’s a drug class with a checkered past. The two ...

PCSK9 was discovered in 2003. In 2003, researchers in France discovered PCSK9 while examining families with extremely high cholesterol and early heart attacks, according to the American Heart ...

WASHINGTON, DC — In order to be cost-effective for patients, providers, and payers, the new proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors would need to cost around $2400 per year ...

Data from a genetics-based study show PCSK9 inhibition does not affect cognition function or dementia risk; however, statin use may be associated with some impaired cognitive performance that is ...

Therefore, "PCSK9 inhibition may represent a novel therapeutic pathway in addition to currently recommended therapeutic approaches for severe COVID-19," conclude the authors, led by Eliano P ...

Compared with placebo, PCSK9 inhibition carried a lower rate of death or intubation in the first 30 days (23.3% vs 53.3%), with numerical reductions in both of the individual components of that ...