Watching mainstream science in America under attack by the US federal and many state governments, most scientists and health ...

The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is ...

From the Human Genome Project to large-scale initiatives like the UK Biobank and The Cancer Genome Atlas (TCGA), the recent ...

For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Phosphatidylserine (PS) is a phospholipid mainly enriched in the inner leaflet of the plasma membrane; however, its role in the nucleus remains unclear. This study describes the presence of PS in the ...

Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis ...

imageimageThis study developed a systematic workflow leveraging transcriptomics and metabolomics to identify input signals for 41 transcription factors in E. coli. A systematic workflow was developed ...

imageimageThere are no cellular or molecular biomarkers diagnostic of myalgic encephalomyelitis (also known as chronic fatigue syndrome [ME/CFS]). We find hundreds of blood-based traits are different, ...

The study explores the transport mechanism of DgoT, a bacterial homolog of SLC17 organic anion transporters.

imageimageRNase H2 dissociates from shortened telomeres allowing the stabilization of RNA–DNA hybrids to drive repair. RNase H1 is subsequently recruited to telomeres to ensure the hybrids are ...

More broadly, these findings contribute to an emerging view in which neuronal health depends on the orchestration of long-range cellular trafficking and local stress responses. By uncovering a system ...