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  1. Scleroderma: Symptoms, Causes & Treatment Options

    Systemic sclerosis has three subtypes — diffuse, limited and sine sclerosis. Diffuse means spread out widely. Diffuse sclerosis causes thickened skin over larger areas at once, including your: …

  2. Types of Scleroderma - Johns Hopkins Medicine

    Diffuse scleroderma is a subtype of scleroderma where excess collagen production causes skin thickening over large areas of the body, usually the fingers, hands, arms, anterior trunk, legs …

  3. Scleroderma - Symptoms and causes - Mayo Clinic

    Jun 15, 2024 · Scleroderma is often categorized as limited or diffuse, which refers only to the degree of skin involvement. Both types can involve any of the other vascular or organ …

  4. Diffuse cutaneous systemic sclerosis | About the Disease | GARD

    Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of systemic scleroderma (systemic sclerosis) and is characterized by skin hardening (fibrosis) and problems in many organs of …

  5. Nov 27, 2021 · TYPES OF SYSTEMIC SCLEROSIS skin, making skin thicker and tougher. You may have excess collagen in their fin ers, or possibly on your face or hands. Some people …

  6. Systemic scleroderma - Wikipedia

    There are two major subgroups of systemic sclerosis based on the extent of skin involvement: limited and diffuse. The limited form affects areas below, but not above, the elbows and knees …

  7. Scleroderma and Systemic Sclerosis (SSc) in Depth - HSS.edu

    Mar 20, 2022 · What is systemic sclerosis (SSc)? There are two main subtypes of SSc – limited and diffuse – which are defined according to the pattern of skin involvement.

  8. Scleroderma: MedlinePlus Medical Encyclopedia

    May 9, 2024 · People with diffuse skin disease (rather than limited skin involvement) may be more prone to progressive and internal organ disease. This form of the disease is classified as …

  9. Diffuse Systemic Scleroderma

    Patients with diffuse systemic scleroderma are more likely to have extensive skin fibrosis on the arms, legs, and trunk and a higher risk of developing internal organ damage, compared to …

  10. Systemic Sclerosis (Scleroderma): Pictures, Symptoms, Causes

    Sep 11, 2025 · Systemic sclerosis (scleroderma) causes the body to destroy healthy tissue. It can change the appearance and texture of your skin and affect other organs. Systemic sclerosis …