Kaamesh | MBBS | Med content creator on Instagram: "If you want the notes, follow and share this video with me — I’ll drop them in your DMs or check my broadcast channel Cotrimoxazole is a fixed-dose combination of sulfamethoxazole and trimethoprim that works synergistically by blocking sequential steps in bacterial folate synthesis, making it bactericidal. Sulfamethoxazole inhibits dihydropteroate synthase, preventing the formation of dihydrofolic acid, while trimethoprim inhibits dihydrofolate